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  • Evidence is increasing that every addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This the main problem regulates reward responses in establishing food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both whenever they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err along the side of caution and let the FDA do its job and demand some investigation be done so that the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their medications.

    Researchers found that participants using this drug for a year, dropped a few pounds within one month and have kept the weight off during the entire 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which might make them more efficient and safer.

    Combo-pilling is the newest fad or also the newest in the future under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that at the time of right now there aren't long term prescription weightloss pills that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug can also raise blood pressure and pulse rate, and shouldn't be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

    Approving a drug using this type of many potentially lethal negative effects is inconsistent while using mission statement in the FDA. The power in the drug manufacturing lobby is blatantly evident inside the approval of numerous drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety in the US.